Richard G Pestell Selected Research

beta Catenin

11/2011	Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition.
9/2006	p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.
4/2006	Construction of a novel DNA decoy that inhibits the oncogenic beta-catenin/T-cell factor pathway.
9/2004	Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice.
4/2004	Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells.
9/2003	Dissecting the roles of beta-catenin and cyclin D1 during mammary development and neoplasia.
9/2003	Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization.
2/2003	IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf.
7/2002	Growth inhibition of human hepatoma cells by acyclic retinoid is associated with induction of p21(CIP1) and inhibition of expression of cyclin D1.
1/2002	Indomethacin induces differential expression of beta-catenin, gamma-catenin and T-cell factor target genes in human colorectal cancer cells.

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Richard G Pestell Research Topics

Disease

183	Neoplasms (Cancer) 09/2023 - 04/2002
110	Breast Neoplasms (Breast Cancer) 04/2023 - 01/2002
46	Carcinogenesis 01/2021 - 01/2002
44	Neoplasm Metastasis (Metastasis) 04/2023 - 05/2003
33	Prostatic Neoplasms (Prostate Cancer) 01/2023 - 01/2002
9	Inflammation (Inflammations) 12/2012 - 02/2003
8	Hypoxia (Hypoxemia) 12/2015 - 04/2010
8	Mitochondrial Diseases (Mitochondrial Disease) 05/2013 - 04/2010
7	Hyperplasia 11/2006 - 10/2002
6	Infections 01/2020 - 05/2003
6	Colonic Neoplasms (Colon Cancer) 11/2019 - 03/2004
5	Adenocarcinoma 06/2015 - 07/2003
5	Chromosomal Instability (Chromosome Stability) 04/2015 - 03/2012
5	Carcinoma (Carcinomatosis) 11/2009 - 07/2002
4	Prostatic Intraepithelial Neoplasia 01/2023 - 02/2011
4	Triple Negative Breast Neoplasms 01/2023 - 06/2013
4	Glioblastoma (Glioblastoma Multiforme) 04/2021 - 05/2013
4	Lymphatic Metastasis 04/2012 - 08/2010
3	Aneuploidy (Aneuploid) 01/2024 - 03/2012
3	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2021 - 03/2004
3	Retinoblastoma (Glioblastoma, Retinal) 01/2019 - 09/2008
3	Hypertrophy 05/2013 - 08/2008
3	Starvation 10/2012 - 08/2011
3	Melanoma (Melanoma, Malignant) 05/2012 - 12/2004
3	Noninfiltrating Intraductal Carcinoma (DCIS) 06/2010 - 04/2009
3	Colorectal Neoplasms (Colorectal Cancer) 07/2008 - 01/2002
3	Ovarian Neoplasms (Ovarian Cancer) 09/2006 - 05/2003
2	Pathologic Processes 01/2020 - 01/2015

Drug/Important Bio-Agent (IBA)

70	Cyclin D1IBA 01/2024 - 04/2002
43	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2002
36	Caveolin 1IBA 05/2013 - 10/2002
22	Lactic Acid (Lactate)FDA LinkGeneric 08/2013 - 06/2010
19	CyclinsIBA 01/2024 - 04/2002
18	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 05/2003
18	Biomarkers (Surrogate Marker)IBA 06/2018 - 06/2009
15	MicroRNAs (MicroRNA)IBA 01/2022 - 08/2008
12	Hormones (Hormone)IBA 01/2021 - 10/2003
12	Tamoxifen FDA LinkGeneric 05/2014 - 08/2008
12	KetonesIBA 05/2013 - 09/2010
11	Transcription Factors (Transcription Factor)IBA 12/2022 - 11/2002
10	LigandsIBA 12/2022 - 04/2004
10	Phenobarbital (Luminal)FDA Link 01/2021 - 01/2006
10	beta CateninIBA 11/2011 - 01/2002
9	Estrogen ReceptorsIBA 01/2023 - 01/2002
9	Androgen Receptors (Androgen Receptor)IBA 01/2021 - 12/2003
9	Messenger RNA (mRNA)IBA 09/2019 - 01/2004
8	CytokinesIBA 11/2019 - 06/2002
8	NF-kappa B (NF-kB)IBA 08/2012 - 02/2003
8	AntioxidantsIBA 06/2012 - 09/2010
7	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2019 - 07/2002
7	CarcinogensIBA 05/2013 - 10/2003
7	Glutamine (L-Glutamine)FDA Link 05/2013 - 09/2010
7	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 10/2012 - 08/2011
7	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 08/2011 - 05/2003
6	Maraviroc FDA Link 09/2023 - 08/2012
6	Estrogen Receptor alphaIBA 04/2023 - 09/2004
6	EnzymesIBA 10/2018 - 12/2003
6	AndrogensIBA 09/2016 - 11/2006
6	Phosphotransferases (Kinase)IBA 04/2015 - 07/2002
6	Estrogens (Estrogen)FDA Link 09/2013 - 10/2003
6	Adenosine Triphosphate (ATP)IBA 12/2011 - 08/2002
5	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 12/2022 - 11/2006
5	ErbB Receptors (EGF Receptor)IBA 06/2018 - 06/2003
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2018 - 05/2003
5	RNA (Ribonucleic Acid)IBA 01/2017 - 10/2004
5	Glucose (Dextrose)FDA LinkGeneric 12/2011 - 02/2005
5	PPAR gammaIBA 12/2009 - 04/2004
4	leronlimabIBA 09/2023 - 10/2019
4	Chemokine CCL5IBA 04/2021 - 08/2012
4	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 04/2021 - 11/2019
4	CCR5 Receptors (CCR5 Receptor)IBA 06/2020 - 08/2012
4	ChemokinesIBA 10/2018 - 12/2006
4	Antineoplastic Agents (Antineoplastics)IBA 05/2018 - 01/2007
4	Sirtuin 1IBA 01/2015 - 11/2006
4	Metformin (Glucophage)FDA LinkGeneric 12/2011 - 04/2011
4	Small Interfering RNA (siRNA)IBA 01/2011 - 08/2008
4	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2011 - 09/2004
3	ChromatinIBA 01/2024 - 11/2012
3	vicrivirocIBA 09/2023 - 08/2012
3	Piwi-Interacting RNAIBA 01/2021 - 03/2012
3	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2017 - 03/2005
3	AgarIBA 02/2016 - 12/2003
3	HoloenzymesIBA 09/2013 - 09/2008
3	Cyclin-Dependent Kinase Inhibitor p16IBA 10/2012 - 06/2003
3	PoisonsIBA 12/2011 - 04/2011
3	Chloroquine (Aralen)FDA LinkGeneric 11/2010 - 06/2010
3	Extracellular Matrix ProteinsIBA 06/2010 - 09/2003
3	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 03/2009 - 09/2004
3	TCF Transcription FactorsIBA 04/2006 - 01/2002
3	JNK Mitogen-Activated Protein KinasesIBA 03/2005 - 05/2003
3	p38 Mitogen-Activated Protein KinasesIBA 01/2005 - 05/2003
2	Indicators and Reagents (Reagents)IBA 04/2023 - 01/2004
2	Monoclonal AntibodiesIBA 01/2021 - 11/2019
2	UbiquitinIBA 09/2019 - 01/2019
2	Cyclin DIBA 01/2019 - 11/2002
2	Progesterone Receptors (Progesterone Receptor)IBA 06/2018 - 01/2006
2	VimentinIBA 06/2018 - 07/2012

Therapy/Procedure

47	Therapeutics 01/2023 - 07/2002
12	Drug Therapy (Chemotherapy) 01/2022 - 06/2003
5	Radiotherapy 02/2016 - 01/2011